WOUND HEALING AND ANTI-INFLAMMATORY EFFECT IN ANIMAL MODELS OF CALENDULA OFFICINALIS

January 20, 2014 by  
Filed under Uncategorized

Scientific research: Wound Healing and Anti-Inflammatory Effect in Animal Models of Calendula officinalis L. Growing in Brazil

Abstract
Calendula officinalis is an annual herb from Mediterranean origin which is popularly used in wound healing and as an anti-inflammatory agent. In this study, the ethanolic extract, the dichloromethane, and hexanic fractions of the flowers from plants growing in Brazil were produced. The angiogenic activity of the extract and fractions was evaluated through the chorioallantoic membrane and cutaneous wounds in rat models. The healing activity of the extract was evaluated by the same cutaneous wounds model through macroscopic, morphometric, histopathologic, and immunohistochemical analysis.

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The antibacterial activity of the extract and fractions was also evaluated. This experimental study revealed that C. officinalis presented anti-inflammatory and antibacterial activities as well as angiogenic and fibroplastic properties acting in a positive way on the inflammatory and proliferative phases of the healing process.

 

 

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CITATION: Evidence-Based Complementary and Alternative MedicineVolume 2012 (2012), Article ID 375671, 7 pages, http://dx.doi.org/10.1155/2012/375671
Copyright © 2012 Leila Maria Leal Parente et al. http://www.hindawi.com/journals/ecam/2012/375671/abs/
FULL ARTICLE: http://www.hindawi.com/journals/ecam/2012/375671/
SOURCE: Open Access article courtesy of Hindawi – Creative Commons Attribution 3.0 Unported Licence

 

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